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Biological Activity |
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo . |
InChI:InChI=1/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
The invention belongs to the field, and ...
We report the synthesis of racetams, a d...
A process for preparing a 2-(1-pyrrolidi...
formaldehyd
2,6-dimethylphenyl isonitrile
4-amino-n-butyric acid
nefiracetam
| Conditions | Yield |
|---|---|
|
In
2,2,2-trifluoroethanol;
at 40 ℃;
for 24h;
Inert atmosphere;
|
39% |
2-pyrrolidinon
2-chloro-N-(2,6-dimethylphenyl)acetamide
nefiracetam
| Conditions | Yield |
|---|---|
|
In
nitrogen; water; toluene;
|
22.2 g (90%) |
|
With
sodium methylate;
In
water; toluene;
|
332 g (90%) |
|
In
nitrogen; water; toluene;
|
22.4 g (91%) |
|
In
tert-butyl methyl ether; nitrogen; water;
|
2.19 g (89%) |
2-pyrrolidinon
2-chloro-N-(2,6-dimethylphenyl)acetamide
formaldehyd
2,6-dimethylphenyl isonitrile