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IDRA 21 is , while it's Molecular Formula is C8H9 Cl N2 O2 S. IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
The CAS number of IDRA 21 is 22503-72-6.
More information of IDRA 21 22503-72-6 are:
|
Synonyms |
IDRA 21 |
|
CAS Number |
22503-72-6 |
|
Molecular Formula |
C8H9 Cl N2 O2 S |
|
Molecular Weight |
232.691 |
|
Density |
1.394g/cm3 |
|
Melting Point |
209 °C(Solv: acetic acid (64-19-7)) |
|
Boiling Point |
405.1°Cat760mmHg |
|
Flash Point |
198.8°C |
|
HS CODE |
2933990090 |
|
PSA |
66.58000 |
|
LogP |
2.93740 |
|
Pka |
9.78±0.40(Predicted) |
IDRA 21, also known as benzothiadiazine derivative, is a positive allosteric modulator of glutamate AMPA receptors. It is a white to off-white crystalline powder that has the ability to inhibit AMPA receptor desensitization, thereby enhancing cognition. IDRA 21 is more capable of crossing the blood-brain barrier than Cyclothiazide (C988960), making it a promising candidate for various applications in the pharmaceutical industry.
InChI:InChI=1/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
Articles related to IDRA 21:
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Article |
Source |
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Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues |
Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi , p. 2099 - 2102 (2018/05/04) |
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ANTIHYPERTENSIVE AGENTS. I. NON-DIURETIC 2H-1,2,4-BENZOTHIADIAZINE |
TOPLISS,SHERLOCK,REIMANN,KONZELMAN,SHAPIRO,PETTERSEN,SCHNEIDER,SPERBER , p. 122 - 127 (2007/10/05) |
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