What is the 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]?

1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is , while it's Molecular Formula is C13H18N2O2S. Used in Pharmaceutical Industry: 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is used as a pharmacological agent for its activity as a dopamine D3 receptor antagonist, which is crucial in the treatment of neurological and psychiatric disorders. Its ability to modulate dopamine signaling pathways makes it a promising candidate for the development of new drug therapies targeting these conditions. Used in Medicinal Chemistry Research: In the field of medicinal chemistry, 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] serves as an interesting target for research due to its unique spirocyclic structure and the presence of a sulfone functional group. 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]'s potential as a lead molecule for the design and synthesis of novel therapeutic agents highlights its importance in the discovery of new drugs for various medical applications. Used in Synthetic Chemistry Research: 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is also utilized in synthetic chemistry research, where its complex structure and functional group provide opportunities for the development of innovative synthetic routes and methodologies. The exploration of its synthesis can contribute to the advancement of chemical techniques and the creation of new compounds with potential applications in various fields.

What is the CAS number for 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]?

The CAS number of 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is 178261-41-1.

What is the 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]?

1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is , while it's Molecular Formula is C13H18N2O2S. Used in Pharmaceutical Industry: 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is used as a pharmacological agent for its activity as a dopamine D3 receptor antagonist, which is crucial in the treatment of neurological and psychiatric disorders. Its ability to modulate dopamine signaling pathways makes it a promising candidate for the development of new drug therapies targeting these conditions. Used in Medicinal Chemistry Research: In the field of medicinal chemistry, 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] serves as an interesting target for research due to its unique spirocyclic structure and the presence of a sulfone functional group. 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]'s potential as a lead molecule for the design and synthesis of novel therapeutic agents highlights its importance in the discovery of new drugs for various medical applications. Used in Synthetic Chemistry Research: 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is also utilized in synthetic chemistry research, where its complex structure and functional group provide opportunities for the development of innovative synthetic routes and methodologies. The exploration of its synthesis can contribute to the advancement of chemical techniques and the creation of new compounds with potential applications in various fields.

What is the CAS number for 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]?

The CAS number of 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is 178261-41-1.

Reputable supplier selling 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] 178261-41-1 with stock

Q: What is 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] (178261-41-1) used for?

1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is a chemical compound characterized by its unique spirocyclic structure, which features two cyclic parts connected through a single atom. 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] contains a sulfone functional group and has been the subject of research for its potential pharmacological properties, particularly as a dopamine D3 receptor antagonist. Its exploration in the treatment of neurological and psychiatric disorders, along with its role in the development of new drug therapies, makes it an intriguing target for synthetic and medicinal chemistry research.

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1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]

CasNo.:178261-41-1
Purity:
Content:
MF:C13H18N2O2S
Packing:
MW:266.364
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Reputable supplier selling 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] 178261-41-1 with stock

Molecular Formula:C13H18N2O2S
Molecular Weight:266.364
PSA：57.79000
LogP:2.56200

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178261-41-1 Process route

: 184289-84-7
benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate

: 178261-41-1
1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; In ethanol; at 65 ℃; for 5h; under 2068.6 Torr;	93%
With ammonium formate; palladium(II) hydroxide/carbon; palladium; In acetic acid; at 50 ℃; for 3h;	93%
With ammonium formate; acetic acid; palladium hydroxide on carbon; palladium 10% on activated carbon; at 50 ℃; for 3h;	93%
With palladium 10% on activated carbon; hydrogen; In ethanol;	93%
With palladium on activated charcoal; ammonium formate; In methanol; for 2h; Reflux;	64%

: 498-94-2
isonipecotic acid

: 178261-41-1
1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 97 percent / K₂CO₃ / H₂O / 58 h / 22 °C 2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C 3: 94 percent / H₂, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr 4: 99 percent / TFA / CH₂Cl₂ / 17 h / 35 °C 5: NaBH₄ / toluene / 0.5 h / -2 °C 6: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C 7: 93 percent / H₂ / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr With sodium tetrahydroborate; oxalyl dichloride; methyl-phenyl-thioether; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 7 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 2: potassium carbonate / 20 °C 3: pyridinium chlorochromate / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane 5: sodium tetrahydroborate / methanol 6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran 7: palladium 10% on activated carbon; hydrogen / ethanol With sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Yield

Multi-step reaction with 7 steps

1: 97 percent / K₂CO₃ / H₂O / 58 h / 22 °C

2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C

3: 94 percent / H₂, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr

4: 99 percent / TFA / CH₂Cl₂ / 17 h / 35 °C

5: NaBH₄ / toluene / 0.5 h / -2 °C

6: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C

7: 93 percent / H₂ / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr

With sodium tetrahydroborate; oxalyl dichloride; methyl-phenyl-thioether; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2: potassium carbonate / 20 °C

3: pyridinium chlorochromate / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane

5: sodium tetrahydroborate / methanol

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

7: palladium 10% on activated carbon; hydrogen / ethanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;

178261-41-1 Upstream products

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benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate
498-94-2
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