Biological Functions

Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.https://labtestsonline.org/tests/creatininehttps://www.kidney.org/atoz/content/what-creatinine

Purification Methods

Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]

General Description

Creatinine is a metabolic byproduct of muscle metabolism, commonly measured in urine to assess kidney function. The study highlights a novel method for its direct determination in urine using MALDI-TOF MS with a selective matrix (DHPT), demonstrating high sensitivity and efficiency compared to traditional techniques. This approach simplifies creatinine quantification, enabling rapid and high-throughput analysis.

Definition

ChEBI: A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.