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Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
pentaethylene glycol
vitamin E succinate
hexa(ethylene glycol) tocopherol succinate
| Conditions | Yield |
|---|---|
|
pentaethylene glycol; vitamin E succinate;
In
toluene;
With
dmap; dicyclohexyl-carbodiimide;
In
chloroform;
|
13.33% |
The CAS number of Tocofersolan is 9002-96-4.
More information of Tocofersolan 9002-96-4 are:
|
CAS Number |
9002-96-4 |
|
Density |
1.01g/cm3 |
|
Melting Point |
34-38oC |
|
Boiling Point |
662.7oC at 760mmHg |
|
Flash Point |
195.4oC |
|
Vapor Pressure |
1.83E-18mmHg at 25°C |
|
Refractive Index |
1.496 |
|
PSA |
100.52000 |
|
LogP |
8.38890 |
Synonyms for Tocofersolan 9002-96-4:Poly(oxy-1,2-ethanediyl),a-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-, [2R-[2R*(4R*,8R*)]]-;D 1T;D-a-Tocopherol polyethylene glycol1000 succinate;D-a-Tocopheryl polyethylene glycol succinate;Eastman Vitamin ETPGS;TPGS;VE-TPGS 1000;VitE-TPGS;Vitamin E-TPGS;d-a-Tocopheryl poly(ethylene glycol) 1000 succinate;d-a-Tocopheryl polyethylene glycolsuccinate;a-Tocopheryl polyethylene glycolsuccinate;
The chemical formula of Tocofersolan is C45H78O11 which containing 45 Carbon atoms,78 Hydrogen atoms and 11 Oxygen atoms,and the molecular weight of Tocofersolan is 795.108.
Tocofersolan, also known as α-Tocopherol polyethylene glycol succinate (T526125), is a synthetic water-soluble vitamin E derivative. It is a polyethylene glycol derivative of α-Tocopherol, which differs from its natural fat-soluble counterparts. Tocofersolan is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
InChI:InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
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HONG KONG ECO INDUSTRIAL LIMITED is a quality supplier of Tocofersolan. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Tocofersolan 9002-96-4.
